USMLE Today

                                                 (from memory)

                                     Master Matabolism Map (Chat GPT, FIRST HALF OF MAP ONLY)

                                                                                                          Fasting state(glucagon, epiniphrine)

 Glycogen

|
| Glycogen phosphorylase

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|Glucose-1-phosphate

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Phosoglutamase (sp?)

|

Glucose-6-phosphate

-First of three branches of metabolism map-

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Glycolysis

|                                               |                                           |

Pyruvate                          PPP (NADPH                      Liver only

|                                                                                           |

|                                                                                    Glucose

-Leads to second branch-

Checking memory....

SUCCESSFUL MEMORIZATION!!!!!

You know how when you are so in love, just saying the other person's name gives you butterflies in your stomach?

"Eleven" "Eleven" "Eleven"

It's a beautiful name. It rolls off the tongue easily. No hard consonants, it sounds almost French it's so mellifluous. 

Eleven is the most beautiful creature I have ever seen. Soft as her name, tiny, completely feminine. When she's trying to look her best to impress me, she will sit with perfect posture and her tail curled demurely around her fore paws, as proper as a sixteen-year old debutante. She is the only creature who has lived with me 24/7 for over 20 years, and we've been exclusive roommates now for over two and one-half years. 

We know each other now. I understand her cat language; she understands my person language. We have our routines, whisker-alarms at day break, soft plaintive meows when she is appealing to me for food. She understands "Where my kitty?" and eagerly greets me at the kitchen window and front door. We have our games, like "I'm gonna get that kitty" as I hide behind the wall separating the kitchen from the living room and then spring out on her. She goes into spasms of excitement. She understands the game and play-fights back, but knows that she can't bite my hand too hard. I let her nibble and gently claw at my hand. 

She knows not to use me as a scratching post when I'm wearing my linen pants. Jeans, no problem. She can nest on my chest except when I'm wearing an Uniqlo tee-shirt, it's too thin.

She has her games. When I'm standing at the toilet with my arms against the wall I'm her step ladder. She jumps up onto the toilet tank, springs up onto my left shoulder and then up onto the shower stall top railing. She used to jump back onto my shoulders when she was ready and I was finished. Now she plays forlorn-cat-stuck-in-a-tree and pretends she's scared and can't get down. She then moves to the furthest place on the shower top from where I am so that I have to strain to squeeze between the toilet to reach up to grab her. Meanwhile, she backs away from me in faux fright and I have to stretch to my right to get a gentle grip on her belly and bring her down...to my shoulders, where she then alights, afraid no longer, having gotten me to indulge her, and onto the floor.

I am totally pussy-cat whipped. 

I am totally in love with "E-lev-en"..."E-lev-en."

Sports "reporting"

 

Public Occurrences June 25, 2026

Florida’s ‘Alligator Alcatraz’ immigration detention center has closed, governor says

It is already being dismantled. This exercise in performative cruelty opened on July 3, 2025 to great fanfare from Grand Old Phascists, including a visit from Phascist Premier Trump, who later posted a photoshopped a pic of President Obama attending. It cost Florida taxpayers $1B-$1.2B.

                                                               With Kristi Gnome

AP

11:30 am:

Putin’s reign may not survive the impending fall of Crimea

On the day [June 24, 2023] of [Yevgeny] Prigozhin’s uprising, Russian dead and wounded numbered just over 223,000. Three years later, Russian losses in Ukraine have swelled more than sixfold, nearing 1.4 million.

Prigozhin understood something Putin could not: The Kremlin is incapable of defeating Ukraine on a conventional military basis.

Putin’s end in Ukraine is coming. Russia cannot continue to sustain these levels of military losses. On Tuesday, NATO Secretary General Mark Rutte noted that Putin is losing as many as 35,000 Russian soldiers each month. He also said that Moscow is spending 50 percent of its government budget on its military. For reference, the U.S. spends only about 15 percent of its federal budget (and no more than 9 percent of its overall combined state and national government budgets) on defense.

...

Putin’s end is coming in Crimea. As we and retired Lt. Gen. Ben Hodges have long argued, Crimea is the decisive terrain of this war. Ukraine does not even have to retake it — it needs only to render it untenable for Russian military use. That day is now fast approaching

The struggle for Crimea will likely culminate in Ukraine finally destroying Putin’s $4 billion Kerch Bridge. Can Putin politically survive the loss of Crimea to Ukraine? We highly doubt it. 

The Hill

As Ukraine seizes ‘first chance to win’, war horrors come home to Russia

President Putin has hinted at peace talks as the economy fails, people flee cities and toxic ‘oil rains’ fall.

USMLE Today

Methylenetetrahydrofolate Reductase, medical acronym MTHFR. 

Now, how are we going to remember that? 🤔

💡

MOTHERFUCKER

Great success!

 

American Exceptionalism

 https://www.buzzfeed.com/daves4/dumb-american-posts-june-24-2026

On a day dedicated to the Miami Heat’s future, Pat Riley was ruminating on, of all things, “extinction.” As in, on a personal level. As in, becoming irrelevant—perhaps the worst fate of all.

It was late June 2014—two weeks removed from the Heat’s crushing Finals defeat to the San Antonio Spurs

Italics in original. 

Ringer

And this from Heavy:

The Miami Heat is the hottest talk of basketball after landing Giannis Antetokounmpo

That term from the Ringer and that half sentnce from Heavy are why I am so proud, relieved really,  about the acquisition of Giannis. The Miami "Heat" and all of Greater Miami, are relevant and the talk of their world again after being "in other action" for 10 of the last 12 years. That bothered me.

Public Occurrences June 24, 2026

 

Pro-Israel politics just took a huge hit in New York

Progressives critical of Israel swept a trio of House races in the home of the nation’s largest Jewish population — a stunning shift that carries national implications for the party.

Politico

9:21 am:

Mamdani Emerges as Kingmaker, Pushing His Slate to a Primary Sweep

Mayor Zohran Mamdani shook the Democratic establishment by helping drive three progressive candidates to victory.

All the winning candidates share Mr. Mamdani’s progressive economic platform, and they each ran campaigns that focused intently on ending American support for Israel, a sign of how far public opinion has shifted on the issue, even in New York.

...

Late Tuesday night, the mayor stood beaming at a victory party in Brooklyn, where supporters chanted “Free, free Palestine” and “D.S.A.” 

...

...the outcome will now cement him as the unquestioned political kingmaker of the nation’s cultural and financial capital and the Democratic Socialists of America as a formidable force.

...

Brad Lander, 56, a close ally whom Mr. Mamdani urged to run for Congress, ran up a staggering 30-point margin in the affluent 10th District in Brooklyn and Lower Manhattan. He defeated Representative Daniel Goldman, a wealthy Levi Strauss heir who had opposed the mayor in last year’s elections and had close ties to the American Israel Public Affairs Committee, the pro-Israel lobby.

nytimes

Oh, did I tell you that the Miami "Heat" got Giannis...? I did, didn't I? Well, good morninga!

Our enemy now is This Israel

"Our enemy now is Canada", 'Witz, aka Isaac Clotiner's bitch at the "Rage Against Hate" conference on Oct. 27, 2025 at Manhattan’s Museum of Jewish Heritage.

'Witz-Bitch noted Prime Minister Mark Carney’s Oct. 16 comments to British podcaster Mishal Husain on her podcast, saying Canada would honour the International Criminal Court’s arrest warrant for Israeli Prime Minister Benjamin Netanyahu, and arrest him if he entered Canada.

Should such an arrest occur, Dershowitz vowed, “I will come up to Canada. I will defend Netanyahu, and I will go after everybody who has tried to arrest him.”

Were 'Witz-bitch on fire outside my condo front door, screaming for help, I would open the door only to see who was making the racket, and would not piss on his disgusting, flaming corpse to put the fire out...And I would not come out of retirement to defend 'Witz-bitch against any charge.

Dershowitz also told the Post he is “in favour of Trump putting tariffs on Canada for its statements regarding Israel and Netanyahu, and even sanctions perhaps."

I am in favor of cutting of all aid whatsoever to the Christian Protectorate of Israel and for canceling all federal and state contracts, and binding American companies to Boycott, Divest, and Sanction the Protectorate. I am also in favor of "tariffs", or any economic or punitive sanction(s) against 'Witz-Bitch for his "statements regarding Israel and Netanyahoo."

National Post October 30, 2025

Expressing outrage over former President Barack Obama’s call for an end to Israeli "occupation," Harvard Law professor emeritus Alan Dershowitz expanded on why he’s never talking to the Democratic president again.

"I think he always had a deep hatred of Israel in his heart. He hid it very well. He called me to the Oval Office and he said to me, 'Alan, you've known me for a long time. You know I have Israel's back.' I didn't realize he meant to paint a target on it," Dershowitz said Friday on "Mornings with Maria."

I have a hatred of This Israel, I don't know how deep, I don't have a hatred depth finder. I have hatred for 'Witz-Bitch and it feels at least as deep.

"He's never been supportive of Israel. And finally, his true feelings have come out now that he's no longer president and doesn't have to be elected," the professor continued. "He has contributed enormously to the problem because he is respected among young people. And if he says the occupation is unbearable and that anything can be done to stop it, he is encouraging people to engage in their antisemitic, anti-Israel and anti-American attitudes. He should be ashamed of himself. He should apologize, but he won't."

I find 'Witz-Bitch anti-American in his attitudes.

Obama spoke at the Obama Foundation's Democracy Forum last Thursday, where he called for a two-state solution and an end to the "occupation," while not clarifying what occupation he meant.

"All of this is taking place against the backdrop of decades of failure to achieve a durable peace for both Israelis and Palestinians," the former president told the forum audience.

He continued: "One that is based on genuine security for Israel, a recognition of its right to exist, and a peace that is based on an end of the occupation and the creation of a viable state and self-determination for the Palestinian people."

The Harvard professor on Friday accused Obama of lying "through his teeth" about what the former president called an "unbearable" occupation of Gaza.

I don't know what President Obama was lying "through his teeth" about unless it's Israel's right to exist: Israel does not have the right to exist. No nation does, not the Toilet Nation, not Canada, not Ukraine. However, to continue the symmetry of this commentary on Wacko 'Witz-Bitch, I will issue a blanket charge that he is lying through his teeth.

"To compare those disputed claims with the rapes, beheadings, burnings, kidnappings, it's just obscene and despicable," Dershowitz said. "And what it does is it lends support to those students basically, who are saying, ‘Well, what Hamas really did was not so bad... It was in response to the occupation.’"

"Although he said that the attacks by Hamas are not justifiable," Dershowitz added, "he made them justifiable because if life really is unbearable, as it's not, then you can do anything you want."

Red Fox

For all the world to see, this is who the Ukrainian people are

 

🌻

Russia Pressures Belarus in Bid to Open New Front in Ukraine War

With Moscow’s prospects faltering on the battlefield, the Kremlin is trying to nudge its closest ally off the sidelines

Wally

Ukraine is defeating Russia. They will win the war against Putin. So say retired U.S. generals, France, the UK, Germany, and, speaking for Canada, Prime Minister Mark Carney.

Volodymyr Zelenskyy is the anti-Netanyahoo, a Jewish head of state fighting a defensive war against a brutal invader who targeted, and targets still, civilians, including with rape even of babies, with kidnappings, and without Trump's help, in fact with his opposition; 

-A Jewish head of state who has not committed genocide or war crimes in retaliation for the genocide and war crimes committed on his people;

-A Jewish head of state who has given the world clarity: There is no question who the good guys and the bad guys are;

-A Jewish leader has made himself and his nation an inspiration not a pariah; 

-And a Jewish leader of a Christian nation who will defeat the Antichrist.

Slava Ukraini

Oh that's right...

Who we gonna get, who we gonna get, who we gonna get!

 

It doesn't seem real

I can't believe the "Heat" actually got Giannis.

"SOMETHING JUST HAPPENED" is already one of my all-time favorite posts here. Look at the time: midnight on the dot. I had to get up at 6:30 today, I'm fucking old, I was all ready to turn in, already too late, when I couldn't resist checking the betting markets one last time. The post previous to that one was at 9:02, almost three hours earlier. I was up for almost another hour, my last post was at 12:57 am. Totally rested today! :)

(My) Projected "Heat" Starters 2026/27

Davion Mitchell
Norman Powell
Andrew Wiggins
Bam Adebayo
Giannis Antetokounmpo

Rotation players:

Bobby Portis
Pelle Larsson
Keshad Johnson
Simone Fontecchio
Myron Gardner

Miami's championship odds immediately plummeted from 30-1 to 18-1.

MIAMI GETS GIANNIS!

OFFICIAL: GIANNIS ANTETOKOUNMPO 

TRADED TO MIAMI!!!!!

Shams Charania

@ShamsCharania

Heat president Pat Riley now makes his long-anticipated new landmark acquisition, with Antetokounmpo joining elite Miami pickups such as LeBron James, Shaquille O’Neal, Chris Bosh, Alonzo Mourning and Jimmy Butler over the past 30-plus years. Riley will pair the two-time NBA MVP and 2021 Finals MVP with Bam Adebayo to lead contention in the Eastern Conference. 

After informing teams that they were open for business at the NBA draft combine in May, Bucks general manager Jon Horst landed a haul with the Heat’s offer that brings high-level starting/rotation players and young talent, as well as significant draft capital.

bleacherreport

 

40m

BREAKING: Giannis has been traded to the Heat per @shams🚨😱

OMG. 🤯🤯🤯

SOMETHING JUST HAPPENED

Giannis Next Team Odds

Kalshi 11:52 PM:

Miami 99%

Stays with Milwaukee or retires 1%

Polymarket 11:53 PM:

Miami 98%

Minnesota <1%

Boston <1%

Milwaukee <1%

Among the many individuals I would like to strangle are Beer's front office. They have a rotating NBA governor, this year it's Jimmy Haslam, last year it was Whit-somebody. But the governor's rotating out are still on the decision-making board. It's a collective, a committee, and you know what they say about horses designed by committees. 

So in that vein there are now reports that there is a "split" on the committee (who'd a thunk it?). Some want to get a star back, that would be Jaylen Brown; some want the greater "quality" of Miami's future draft picks. You think beautiful women make a man go cross-eyed? Well, when you're a billionaire sports team owner, the beautiful women are those nameless, faceless, grade-schoolers, middle-schoolers and high-schoolers who make up future  draft classes. Billionaire owners see swans swimming in the future, there are no ugly ducklings. They see that Jaylen Brown is a knockout, but compared to what the imagination can see, he's a beauty for sure, but one who is getting a little long in the tooth and has a mole here and there.

That's the holdup right now (reportedly). That's why I want to strangle Beer's committee. The cognos now say the trade will be announced right prior to the draft, tomorrow at 8 pm. 

Yes

 

Ira Winderman
@IraHeatBeat

This never was going to be easy. If there is a Heat deal, it likely will be completed later, due to cap/calendar rules. If there is not, then it would seem the time for Pat Riley to talk.

Yes, and his talk should be short, "I resign."

If he misses on another "whale" it will be because of the same reason that he missed on others: he overvalues his roster. He can't make reasonable judgments anymore.

 Jake Fischer

@JakeLFischer

A split faction of Milwaukee’s decision makers, sources say, is deciding between Boston’s package for Giannis Antetokounmpo built around Jaylen Brown — where the Bucks also hold particular Hugo Gonzales interest, as @TheSteinLine reported last night — plus limited draft capital, compared to Miami’s offer of younger pieces — featuring Tyler Herro, Kel’el Ware, Jaime Jaquez —  and multiple first-round picks. 

The established MVP candidate versus greater overall value is what this whole saga has boiled down to one day before the NBA Draft.

CelticsUnite

@CelticsUnite18

Giannis is willing to extend with 2 teams.

1 is offering Jaime Jaquez and Tyler Herro

The other is offering Jaylen Brown

How is this even a conversation?

8:26 PM · Jun 16, 2026

87.7K Views

👆Bound to be beat: that is how I have always seen the "Heat's" offer.

As your lifespan shortens, you, or at least I, have a corresponding decrease in tolerance for people and events that waste my time. I could strangle someone right now but there are so many contestants and anyway, it would make my arm muscles hurt.

Anticlimactic Antetokounmpo

In 71 years of sports following I have never seen horseshit like this.

Public Occurrences June 22, 2026

Keir Starmer, British Prime Minister, Labour Party Leader, Resigns After Inept Tenure

I Like Ike lol

 DERSHOWITZ: The other day there was a fund-raiser event on the Vineyard sponsored by Democratic Jews. The Jewish Democrats is the name of the organization, the Jewish Democrats. Now, if you ask a hundred people to name the five most well-known Jewish Democrats on Martha’s Vineyard . . .

CHOTINER: You want me to do that now, or are you saying hypothetically?

DERSHOWITZ: No, hypothetically.

Oh my fucking God, 'Witz, first of all 'Witz, you are "disgusting" as Larry David said, but the larger point is, you were killed during that interview, you died, you're DEAD. You're dead now! I don't know who your wife or family, or friends, but you don't have any, so your wife or family, I don't know who they got to impersonate you these last four years but that's not you, you're dead and buried under an olive tree in Israel, or you were cremated and your ashes buried under an olive tree in Israel as fertilizer but you, your ashes or your disgusting corpse, poisoned the olive tree and killed it.

The markets are aligning, the intel is aligning, Greg Cote is aligned...

Every sign without exception, and combined, is that Giannis Antetokounmpo is headed to the Miami "Heat".

The "Heat" and "Bucks" are putting the "finishing touches", in the wording of NBA reporter Evan Sidery, on the trade. It is going to be a complex three-team or four-team round robin to get Beer what it needs. That has been the reason for the holdup. Detroit is the most-mentioned other team. The heaters most often mentioned as going are Tyler Herro, Kel'el Ware, and Jaime Jaquez, Jr. (plus draft picks).

Ukraine is Winning the War with Russia🌻

Ukrainian attacks prompt Russian-held Crimea to halt civilian gasoline sales

AP

Canada, France, Germany, the UK.: "We, the Germans, the British, and the French – all share the view that the situation in this war has fundamentally changed. It’s only a matter of time, but Putin will lose this war."– Mark Carney. CNN

CBS

U.S. Generals