Sexual identity, androgyny, sexual transference: those are the themes of The Garden of Eden. 

Gregory Hancock Hemingway, Ernest's third son, became a physician like his grandfather (Gregory lost his license due to alcoholism.). He also tried to become a woman. He had partial gender reassignment surgery and went by the names Gloria Hemingway and Vanessa Hemingway. He was arrested on charges of indecent exposure and died in custody at the Women's Detention Center in Miami, FL in 2001. And I did not know that.